Zeolites are microporous crystalline aluminosilicates derived from the reaction of volcanic rocks, ash layers and alkaline groundwater. The Atlas of Zeolite Framework Types currently recognizes about 218 different Zeolite structures, of which 40 natural zeolites are known. Natural zeolites are listed by the USA Food and Drug Administration for human consumption (FDA GRAS Listings, 2006) and considered as non-toxic by the World Health Organization’s International Agency for Research on Cancer (IARC, 1997). Moreover, Codex Alimentarius Commission (1999) lists some zeolites as a granted substance in Organic Food Production and Plant Protection. Most of us are familiar with the zeolites used in water softener systems. The zeolite core of the water softener absorbs large amounts of metals like calcium and magnesium from the water. Periodically, the zeolite in your water softener is flushed with highly concentrated salt water to flush out the metal ions and regenerate the zeolite for more absorption. The most common forms of zeolites used in water softeners are the natural aluminosilicates, gluconites (i.e. greensand), and synthetic permutite. FDA GRAS List. Database of Select Committee on GRAS Substances (SCOGS) Reviews. Sodium Aluminosilicates. (http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=281). European Food Safety Authority (EFSA) Panel on Food Contact Materials, Enzymes, Flavorings and Processing Aids (CEF). 2013a. EFSA Journal 11, 3155. European Food Safety Authority The Panel of Additives and Products or Substances used in Animal Feed (FEEDAP). 2013b. EFSA Journal 11, 3039. IARC., 1997a. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement. Silica, Some Silicates, Coal Dust and para-Aramid Fibrils Vol 68 p. 506. IARC., 1997b. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, “Zeolites other than Erionite” Vol 68 p.307-333. SCOGS, 1979. Database of Select Committee on GRAS Substances (SCOGS) Reviews. Sodium Aluminosilicates. (http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=281). lARC. 1987. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 7, Overall Evaluations of Carcinogenicity: An Updating of lARe Monographs. Volumes 1 to 42, Lyon, p. 203.

Lab Grown zeolite is made in the laboratory under controlled conditions and with controlled composition. Mined zeolite is extracted from the earth in its natural form and is usually processed to remove attached impurities. Lab Grown zeolite can only contain the elements that are put in as part of the controlled process. Mined zeolite may contain trace amounts of many different kinds of elements. Of the 245 unique zeolite frameworks that have been identified by the International Zeolite Association Structure Commission, over 40 are naturally occurring. Naturally occurring zeolites are rarely pure and are contaminated to varying degrees by other minerals, metals, quartz, or other zeolites. Some of these impurities are simply adsorbed inside the zeolite’s pores, while others are an integral part of the structure. Acid treatments at high temperatures can remove many of these impurities, but as more structural atoms are extracted, the integrity of the zeolite framework becomes compromised, and the important toxin-binding cages begin to collapse. At this point, the zeolite becomes increasingly less effective as regions inside the structure become blocked. In other words, increasing purity is balanced by decreasing function, and it is difficult to completely purify a naturally occurring zeolite from all its impurities and still retain full potency. There are no such things as “different-sized zeolite molecules”. The zeolite in Advanced TRS is not a molecule of zeolite, it is a cluster of multiple zeolite cages that together forms an object that is only nanometers large. It is not possible to create a structural formula for a specific particle size, instead structural formulas are created on the basis of the zeolite’s unit cell, the minimum size repeating unit. This formula is the same regardless of particle size. A representation is given by (Na2, K2, Ca)3Al6Si30O72·24H2O. The crystal structure of clinoptilolite has large 12-ring pores, the effective pore size of the zeolite excludes molecules larger than ~0.9 nm. Because of its wide use in agriculture and industry Clinoptilolite has been named the mineral of the 21st century by The International Mineralogical Association. Clinoptilolite has been used with success in animal feed at less than 2% by weight and for the purpose of an anti-caking flow agent. To produce pure, synthetic clinoptilolite, silica, alumina, and alkali sources with initial Si/Al ratio from 3.0 to 5.0 are heated in an autoclave for 1–10 days at a temperature range from 120 to 195 °C. The Clinoptilolite begins to assemble in tiny crystals, whose crystallization rate and crystallinity is controlled by seeding and manipulation of the reaction conditions. Instead of direct heat, microwave, ultrasound and high pressure may be used. Farjoo A, Sawada JA, Kuznicki SM. Manipulation of the pore size of clinoptilolite for separation of ethane from ethylene. Chemical Engineering Science. (2015) 138:685-688. Kowalczyk P, Sprynskyy M, Terzyk AP, Lebedynets M, Namieśnik J, Buszewski B. Porous structure of natural and modified clinoptilolites. J Colloid Interface Sci. (2006) properties of natural zeolite – Clinoptilolite – As a sorbent. Environment Protection Engineering (2012) 39(1):139. Moliner M, Willhammar T, Wan W, González J, Rey F, Jorda JL, Zou X, Corma A. Synthesis design and structure of a multipore zeolite with interconnected 12- and 10-MR channels. J Am Chem Soc. (2012) ;134(14):6473-8.

Clinoptilolite is a naturally occurring hydrated alkali aluminosilicate that is one of the most abundant minerals in the zeolite family. Its structure consists of an outer framework of silica and alumina tetrahedra, within which clusters of water molecules and exchangeable cations (e.g., calcium, potassium, sodium) migrate freely, while larger metals preferentially gather inside. See: https://youtu.be/RZhhrIC5QDk Health A Tox Hazard Subst Environ Eng. (2012) 47(3):337-50. Sakthivel A, Iida A, Komura K, Sugi Y. The beta-zeolite synthesized by dry-gel conversion method without the use of sodium hydroxide: characterization and catalytic behaviors. J Nanosci Nanotechnol. (2009) 1:475-83. Li CH, Huang KL, Chi YN, Liu X, Han ZG, Shen L, Hu CW. Lanthanide-organic cation frameworks with zeolite gismondine topology and large cavities from intersected channels templated by polyoxo-metalate counterions. Inorg Chem. (2009) 48(5):2010-7. Zhang D, Zhang RQ. Silica nanoarchitectures with tailored pores based on the hybrid three- and four-membered rings. J Phys Chem B. (2006) 110(31):15269-74; Mintova S, Olson NH, Valtchev V, Bein T. Mechanism of zeolite A nanocrystal growth from colloids at room temperature. Science. (1999) 283(5404):958-60. (Ng TYS, Chew TL, Yeong YF, Jawad ZA, Ho CD. Zeolite RHO Synthesis Accelerated by Ultrasonic Irradiation Treatment Sci Rep (2019) 9:15062. Gordina NE, Prokof’ev VY, Kul’pina YN, Petuhova NV, Gazahova SI, Hmylova OE. Effect of ultrasound on the synthesis of low-modulus zeolites from a metakaolin. Ultrasonics Sonochemistry. (2016) 33: 210-219. Effects of ultrasound on the synthesis of zeolites: A review. Journal of Porous Materials. (2013) 20: 285–302. Jin H, Ansari MB, Park SE. Mesoporous MFI zeolites by microwave induced assembly between sulfonic acid functionalized MFI zeolite nanoparticles and alkyltrimethylammonium cationic surfactants. Chem Commun (2011) 14;47(26):7482-4. Panzarella B, Tompsett GA, Yngvesson KS, Conner WC, Microwave Synthesis of Zeolites. 2. Effect of Vessel Size, Precursor Volume, and Irradiation Method. J. Phys. Chem. B (2007), 111, 44, 12657-12667 Conner WC, Tompsett G, Lee KH, Yngvesson KS. Microwave Synthesis of Zeolites: 1. Reactor Engineering. J. Phys. Chem. B (2004), 108, 37: 13913-13920.

AdvancedTRS contains nano-clinoptilolite, which is a smaller version of micronized clinoptilolite, with stable chemical and physical characteristics. Its main advantage comes from its tremendously higher pore accessibility and ability to penetrate more effectively to wherever toxins are found. Clinical studies reported to date do not dispute that nano-clinoptilolite is a safe and effective product. Clinoptilolite itself has been shown to: Bind heavy metals and over 80,000 toxins Adjust the balance of vital nutrients like iron & calcium Support intestinal microflora and pH Promote healthy immune function AdvancedTRS is a REFINED formula utilizing nanotechnology to enhance the body’s natural detoxification efforts at the cellular level. https://www.youtube.com/watch?v=IwIe4A4zx6E

The classic definition is that a particle is considered to be nano-size when it is less than 100 nanometers in size. This definition is a non-limiting functional definition that arose when scientists discovered unique properties in certain materials with nanometer-sized dimensions. https://youtu.be/B-nrrstoO_E

The particle sizes in AdvancedTRS are between 10 and 250 nanometers, with the most common size somewhere in-between those two values.. The active site, or pore size is approximately 0.9 nanometers. https://youtu.be/sA4saOn_ykk

The strong attraction of zeolites for toxins is the result of the way the elements oxygen, silicon, aluminum, and alkali metals (e.g. lithium, sodium, potassium) are arranged inside the material. The Silicon-Oxygen and Aluminum-Oxygen bonds that create the nanometers-sized hollow cages inside the zeolite are bulky and rigid. The strong bonds between these elements leave the interior space within the cage with a negative electrical charge, and elements and molecular fragments with positive charge are strongly adhered, sometimes by multiple connections, making it very difficult for the captured species to escape. Zeolites, like that in Advanced TRS, have the capability of absorbing any metal found in a positively charged state. The actual amounts will depend on which element, if it is a combination of elements, and the form of these elements (i.e. if they are dissolved or part of larger metallo-organic complexes.). Noble metals like gold and platinum are usually neutral and would have little affinity to advanced TRS. https://youtu.be/w6G3QM0vz8A Positive charge means that an object is not electrically neutral but has fewer balancing negative charges than positive charges. The concept of charge comes from everyday observation of static cling in the laundry. The reason why you get static cling, is that the two objects, you and your laundry item, oppositely match each other electrically so that when they come together they are electrically neutralized and stick. At the microscopic level, it means one has more electrons than it needs and the other does not have enough. When the two things come together the extra electrons from one can be donated to the other object. Sometimes the electrons can’t really leave their parent object so the two objects “cling” together. When you get an electrical shock on touching something, it means the extra electrons from one object have jumped across the air, into the other object, bringing the two items together. That creates a “spark” and you might feel a pain or pinch at the point closest to contact.

AdvancedTRS is different in many ways: Through Coseva’s proprietary processes, the zeolite particle is nano-sized and stabilized in water which allows it to be easily assimilated. Additionally, AdvancedTRS is the purest form of clinoptilolite available because it is Lab Grown in a clean laboratory facility, using state of the art technology and science.The Lab Grown zeolite in AdvancedTRS is an improvement on nature since its synthesis occurs from only well-characterized precursors, in a clean, sterile environment. https://youtu.be/bm5YtKqbeNs

It depends on the individual, as each person’s digestive system works a little differently. In the 1980’s, Mayo Clinic researchers measured digestion time in 21 healthy people. Total transit time, from eating to elimination in stool, averaged 53 hours. The average transit time through just the large intestine (colon) was 40 hours, with significant difference between men and women: 33 hours for men, 47 hours for women. Taking AdvancedTRS every day will result in a steady state level of zeolite in your digestive tract. Once you stop taking AdvancedTRS it takes a couple days for Advanced TRS to fully clear out. Metcalf AM, et al. Simplified assessment of segmental colonic transit. Gastroenterology. 1987; 92:40. https://youtu.be/VUr842PKWmg

Because the zeolite molecule in Advanced TRS is surrounded by layers of water, it can travel in the body wherever water goes.

Laboratory-made clinoptilolite zeolite and ultra-purified water.

No, it’s filtered with standard polypropylene pharmaceutical grade filters then through a reverse osmosis filter to produce 18 megohm water.

Advanced TRS will not leach metals from a fully processed medical implant or device. They will not be attracted to or removed by the zeolite.

No. Copper IUDs work as a physical barrier to conception, and AdvancedTRS has no impact on this function.

Iodine is negatively charged and will not bind to AdvancedTRS clinoptilolite – which is negatively charged. Zinc and silver – being positively charged – may have some affinity for the zeolite. Coseva recommends that micronutrient minerals be taken at least 4 hours before or after the TRS. Once in the body, minerals which are essential for health, are very quickly bonded to other substances which neutralize any ionic charge and therefore preserve them for use by the body. Pollutants, like heavy metals which are not useful for health, are not protected by the body and can therefore be picked up by the zeolite. The 4 hour dose interval is to allow the body to protect what it needs. Iodine, which is not a metal, will be used by the body and the zinc will also be protected by the body. The silver (elemental), as a noble metal, has no charge to attract the zeolite.

As x-rays are an ionizing radiation and not a particle/molecule, the x-ray will not have a negative effect on the zeolite in Advanced TRS.

Yes. Clinoptilolite’s ability to capture toxins is well documented on pubmed.gov and medline.gov. Some of these studies are referenced in our white paper, but there are so many that it is by no means a comprehensive list.

REMOVE, REPAIR, & RESTORE Detoxify and Replenish Coseva’s Advanced Fulvic offers an optimal combination of fulvic acid, humic acid, and unique micronutrients. While other fulvic/humic products simply take their material from a single source (which is often high in humic acid and very low on micronutrients) Advanced Fulvic is formulated to combine material from several specialized sources to supply a balanced amount of all three components – fulvic acid, humic acid, and micronutrients – in a single serving. The targeted natural materials combined in Advanced Fulvic have been optimized for: Assisting with total body detox of heavy metals, pesticides, and other toxins Providing 1000x the antioxidant power of popular “superfoods” to help the body with cellular-level repair Supporting Healthy Immune Response Helping optimize the gut microbiome and reduce “leaky gut” Contributing to healthy inflammation response Improving mental clarity and memory

Take once daily by mixing 1 ml with 16 ounces of non-chlorinated water or your favorite beverage. USAGE WARNINGS If you are pregnant, breastfeeding, under the age of 13, or taking prescription medication, consult your physician prior to use. Allergy Warning: Made in a facility that also processes soy and egg.

Fulvic Acid (as mineral complex) – 40mg Humic Acid (as mineral complex) – 60mg Micronutrients** (as mineral complex) – 90mg **Contains over 70 naturally occurring fulvic and humic bio-mass vegetal materials, trace minerals, trace amino acids, and antioxidants presented within the original humate source. Other Ingredients: Purified water.

RELIEF & RELAXATION Promote Balance for Body & Mind CBD is a natural compound derived from the cannabis plant, which has been used for thousands of years to promote a sense of wellness and balance. Today, millions of users across the globe use CBD, as in some cases it may: Reduce Stress (Without a “High”) Promote a Sense of Calm & Wellbeing Soothe Aches and Discomfort Support Healthy Immune Response Improve Sleep Quality By applying proprietary nanotechnology processes, Coseva enhances CBDs natural effects to deliver a sprayable product that is: 5-10x More Potent than Regular CBD Broad Spectrum, Containing Beneficial Terpenes, but 0% THC (defined as being undetectable using typical analytical methods). Ultra-pure and Contaminant-Free Non-GMO, US Grown, and 100% Organically Grown Great Tasting (Reduced “Hempy” Taste) Coseva’s innovative Advanced CBD is truly a next-gen CBD product, maximizing purity and bioavailability while reducing some of CBD’s traditional drawbacks.

Coseva's Advanced CBD is cleaner, faster acting and more effective than regular oils or tinctures, delivering one-of-a-kind nano-enhanced benefits you can feel.

Use daily. Take 2 sprays in the morning and 3 sprays in the evening by mouth. USAGE WARNINGS Coseva always recommends that the individual consult with their physician before beginning use of any new product and to advise their physician of the use of any and all health or wellness products. AdvancedCBD is not medicine. Coseva does not engage in the diagnosis or treatment of diseases. Coseva cannot recommend specific uses for AdvancedCBD, other than in assisting the body in its normal healthy processes. KEEP bottles OUT OF REACH OF CHILDREN. Do not use if tamper evident seal is broken. Store at controlled room temperature (59°-86° F). Avoid excessive heat and humidity.

CBD – Broad Spectrum Hemp (0 mg THC): 20mg per serving Other Ingredients: ultra-pure water, medium chain triglyceride oil (coconut), organic stevia leaf extract, organic sunflower lecithin, natural flavors, natural preservatives (sodium propionate, potassium sorbate, citric acid). 0% THC** ORGANICALLY GROWN HEMP NON-GMO *Manufactured in a facility that also processes soy, tree nuts, and egg. ** 0% THC defined as being undetectable using typical analytical methods

Coseva’s Advanced CBD is a “broad spectrum” formulation, which means it naturally contains most of the beneficial cannabinoids, terpenes, and flavonoids extracted from the hemp plant, with the exception of psychoactive THC, which has been removed. As opposed to CBD “isolate” formulations (which remove many beneficial parts of the extracted hemp oil), and “full spectrum” formulas (which include THC and may cause unwanted side effects), Coseva’s “broad-spectrum” approach means you can feel confident in knowing your body is getting everything it needs while minimizing any potentially harmful or unnecessary side effects. Coseva’s Advanced CBD promises to always have 0% THC content (defined as being undetectable using typical analytical methods).